By M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview
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Extra info for Acetylcholine. An Approach to the Molecular Mechanism of Action
Numerous investigations of the action of pharmacological agents on brain function also lend support to the idea of the presence of cholinergic synapses in the brain. Cholinopositive (cholinomimetics and anticholinesterases) and cholinolytic preparations exert actions, the character of which is in line with the proposition that there are cholinergic synapses in the brain (see Votava, 1967). Cholinomimetics (nicotine, arecoline, oxotremorine) and anticholinesterases evoke tremor and convulsions of central origin, which are prevented by cholinolytics.
Belleau put forward the view that definite changes must also occur in the cholinoreceptor to enable it to combine with ACh, or with other cholinergic substances. ACh and cholinomimetic substances induce "specific" conformational changes, which lead to the increase in permeability of the membrane to ions. The adsorption of blocking substances is associated with "non-specific" conformational changes in the ChR, occurs mainly through the formation of "hydrophobic bonds", and does not increase the permeability of the membrane to ions.
An inhibitory effect develops. It is precisely such a selective increase in the permeability of the membrane of the muscle cell to K + ions that occurs under the influence of the vagus nerve in the heart of vertebrates such as frog and cat (see Eccles, 1965a). e. is also manifested as a hyperpolarization. The cholinergic inhibitory synapses, found in some neurones of the central nervous system of the snail, are an example of this (Kerkut and Thomas, 1963a, b). In the central nervous system of vertebrates two substances apparently play the role of inhibitory mediators: in the spinal cord, glycine, and in the brain, gamma-amino-butyric acid (GABA) (Eccles, 1969).
Acetylcholine. An Approach to the Molecular Mechanism of Action by M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview