Get Alternative Splicing and Disease (Progress in Molecular and PDF

By Philippe Jeanteur

ISBN-10: 3540344489

ISBN-13: 9783540344483

Splicing of basic RNA transcript is a quasi-systematic step of gene expression in better organisms. this can be the 1st ebook to spotlight the scientific implications, i.e. ailments, as a result of substitute splicing. replacement splicing not just significantly raises protein range but additionally bargains quite a few possibilities for aberrant splicing occasions with pathological results. The publication additionally outlines attainable ambitions for treatment.

Show description

Read or Download Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) PDF

Similar molecular biology books

Get Computational Analysis of Biochemical Systems: A Practical PDF

A real figuring out of genetic and metabolic functionality and layout is facilitated via mathematical and computational equipment for reading biochemical structures. This hands-on reference teaches biochemists and molecular biologists using glossy computational tools for the research of advanced biomedical platforms requiring a modest mathematical historical past.

Download e-book for kindle: PCR Protocols (Methods in Molecular Biology) by Daniel J. Park

Identified for flexibility and robustness, PCR strategies proceed to enhance via various advancements, together with the identity of thermostable DNA polymerases which express a variety of homes to fit given purposes. PCR Protocols, 3rd variation selects lately constructed instruments and methods, contributed by means of field-leading authors, for the numerous price that they upload to extra typically proven tools.

Download e-book for kindle: Microarray Quality Control by Wei Zhang

Microarray expertise presents researchers within the lifestyles sciences with a progressive software for measuring gene expression. besides the fact that, this hugely built strategy contains a number of steps, from pattern choice to information research, every one at risk of in all likelihood expensive error. with no sound qc, experimental microarrays might produce lifeless or, even worse, deceptive effects.

Read e-book online Gametogenesis, Early Embryo Development and Stem Cell PDF

This short deals a concise, convenient assessment of the most thoughts regarding Embryology, revisited throughout the novel recommendations which are utilized day-by-day in stem phone learn and phone remedy orientated investigations. it's according to 3 major parts: -The technique occupied with lady gamete differentiation and maturation.

Extra resources for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)

Example text

2001) Hasegawa et al. (1994) Gu et al. (2001) GTGATTCGCGTGGGT GTGATTCGGGTGGGT Porphobilinogen deaminase Fumarylacetoacetate hydrolase Pyruvate dehydrogenase E1 alpha TNFRSF5, tumorCTACAGGG necrosis factor CTACTGGG receptor superfamily, member 5 (CD40); CCTATGGGCCGTT CYP27A1 CCTATGTGCCGTT GGGATCATCGTGGGA Fibrillin-1 GGGATCATTGTGGGA MNK Menkes disease Bardet-Biedl Syndrome MGC1203 Zavadakova et al. (2002); Zavadakova et al. (2005) Badano et al. (2006) Methionine synthase TCAGCCTGAGAGGA TCAGCCCGAGAGGA GGCCTTCG GGCCTTTG Matern et al.

Nat Struct Biol 10: 120–125 Castle J, Garrett-Engele P, Armour CD, Duenwald SJ, Loerch PM, Meyer MR, Schadt EE, Stoughton R, Parrish ML, Shoemaker DD, Johnson JM (2003) Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing. Genome Biol 4: R66 Celotto AM, Lee JW, Graveley BR (2005) Exon-specific RNA interference: a tool to determine the functional relevance of proteins encoded by alternatively spliced mRNAs. Methods Mol Biol 309: 273–282 Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, Winkler J, Lockhart DJ, Morris MS, Fodor SP (1996) Accessing genetic information with high-density DNA arrays.

Fehlbaum P, Guihal C, Bracco L, Cochet O (2005) A microarray configuration to quantify expression levels and relative abundance of splice variants. Nucleic Acids Res 33: e47 Feldkotter M, Schwarzer V, Wirth R, Wienker TF, Wirth B (2002) Quantitative analyses of SMN1 and SMN2 based on real-time LightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy. Am J Hum Genet 70: 358–368 Frey UH, Nuckel H, Dobrev D, Manthey I, SAndalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W (2005) Quantification of G protein Gαs subunit splice variants in different human tissues and cells using pyrosequencing.

Download PDF sample

Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) by Philippe Jeanteur

by Richard

Rated 4.03 of 5 – based on 7 votes