Get Alternative Splicing and Disease (Progress in Molecular and PDF

By Philippe Jeanteur

ISBN-10: 3540344489

ISBN-13: 9783540344483

Splicing of basic RNA transcript is a quasi-systematic step of gene expression in better organisms. this can be the 1st ebook to spotlight the scientific implications, i.e. ailments, as a result of substitute splicing. replacement splicing not just significantly raises protein range but additionally bargains quite a few possibilities for aberrant splicing occasions with pathological results. The publication additionally outlines attainable ambitions for treatment.

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Extra resources for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)

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2001) Hasegawa et al. (1994) Gu et al. (2001) GTGATTCGCGTGGGT GTGATTCGGGTGGGT Porphobilinogen deaminase Fumarylacetoacetate hydrolase Pyruvate dehydrogenase E1 alpha TNFRSF5, tumorCTACAGGG necrosis factor CTACTGGG receptor superfamily, member 5 (CD40); CCTATGGGCCGTT CYP27A1 CCTATGTGCCGTT GGGATCATCGTGGGA Fibrillin-1 GGGATCATTGTGGGA MNK Menkes disease Bardet-Biedl Syndrome MGC1203 Zavadakova et al. (2002); Zavadakova et al. (2005) Badano et al. (2006) Methionine synthase TCAGCCTGAGAGGA TCAGCCCGAGAGGA GGCCTTCG GGCCTTTG Matern et al.

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Fehlbaum P, Guihal C, Bracco L, Cochet O (2005) A microarray configuration to quantify expression levels and relative abundance of splice variants. Nucleic Acids Res 33: e47 Feldkotter M, Schwarzer V, Wirth R, Wienker TF, Wirth B (2002) Quantitative analyses of SMN1 and SMN2 based on real-time LightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy. Am J Hum Genet 70: 358–368 Frey UH, Nuckel H, Dobrev D, Manthey I, SAndalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W (2005) Quantification of G protein Gαs subunit splice variants in different human tissues and cells using pyrosequencing.

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Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) by Philippe Jeanteur


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