Alzheimer's disease : life course perspectives on risk - download pdf or read online

By Amy Borenstein, James Mortimer

ISBN-10: 0124171540

ISBN-13: 9780124171541

ISBN-10: 0128045388

ISBN-13: 9780128045381

Alzheimer's sickness: Lifecourse views on hazard relief summarizes the growing to be physique of data at the distribution and motives of Alzheimer’s ailment (AD) in human populations, offering the reader with wisdom on how we outline the ailment and what its hazard and protecting components are within the context of a life-course process.

At the realization of the publication, the reader will comprehend why Alzheimer’s affliction most probably starts at belief, then progresses via early-life and grownup probability components that eventually effect the stability among pathologic insults within the mind and the facility of the mind to change illness signs. not like edited volumes that could have little team spirit, this booklet specializes in an built-in life-course method of the epidemiology of dementia, particularly, Alzheimer’s sickness.

  • Reviews the present technological know-how surrounding Alzheimer’s disease
  • Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
  • Utilizes a life-course technique, offering a singular and built-in view of the evolution of this ailment from genes to mind reserve
  • Uses the ‘threshold model’—a concept first defined by way of Dr. Mortimer and broadly accredited today—which contains the belief of threat elements for the pathology and expression of the illness
  • Proposes that bettering mind wellbeing and fitness via modifiable behaviors can hold up sickness onset till a later age
  • Examines the way forward for prevention of Alzheimer’s disorder, a topic of significant present interest

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Extra info for Alzheimer's disease : life course perspectives on risk reduction

Example text

Because of this and the high sensitivity of visuospatial tests to AD pathology, neuropsychological batteries aimed at detecting AD generally include one or more tests of complex visual construction or perception. NEED FOR STANDARDIZATION The manner in which the criteria are operationalized in the clinical research setting is critical to the identification of cases of dementia. For example, there has long been heated debate about how “a decline from a previous level of social or occupational functioning” should be interpreted.

Because of the significant expense involved in acquiring imaging on all individuals from a population-based study, the implementation of these criteria in epidemiologic studies has not yet occurred, and it remains to be seen whether this can be realistically done or whether the new criteria will be implemented principally into clinical research studies and trials. Since the studies described in this book have all used the 1984 and not the 2007/2011 criteria, when we refer to the NINCDS-ADRDA criteria in subsequent chapters, we will be referring to the 1984 criteria.

However, at autopsy the presence of disease pathology, even severe pathology, is detected frequently when no symptoms are present prior to death. , 1997). Understanding why this occurs and what it means for epidemiologic studies of the disease is important to our understanding of the risk factors for AD as well as the role played by brain reserve in the prevention of the dementia of AD. 1 shows the two principal brain lesions that characterize the pathology of AD, the neurofibrillary tangle, and the neuritic plaque.

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Alzheimer's disease : life course perspectives on risk reduction by Amy Borenstein, James Mortimer

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