An Introduction to Molecular Biotechnology- Fundamentals, by Michael Wink PDF

By Michael Wink

Molecular biotechnology keeps to triumph, as this textbook testifies - edited via one of many educational pioneers within the box and written via skilled execs. This thoroughly revised moment variation covers the full spectrum, from the basics of molecular and cellphone biology, through an outline of normal tools and applied sciences, the appliance of many of the "-omics", and the advance of novel drug pursuits, correct as much as the importance of procedure biology in biotechnology. the entire is rounded off via an creation to business biotechnology in addition to chapters on corporation starting place, patent legislations and advertising.
the recent variation features:
- huge layout and whole colour throughout
- confirmed constitution based on fundamentals, equipment, major issues and financial perspectives
- New sections on approach biology, RNA interference, microscopic concepts, excessive throughput sequencing, laser functions, biocatalysis, present biomedical functions and drug approval
- Optimized instructing with studying ambitions, a thesaurus containing round 800 entries, over 500 vital abbreviations and additional reading.
the single source if you are heavily attracted to the topic.

Bonus fabric to be had on-line for free: www.wiley-vch.de/home/molecbiotech

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Extra info for An Introduction to Molecular Biotechnology- Fundamentals, Methods and Applications

Sample text

Significant activation energy has to be overcome in order to start an energy-consuming chemical reaction. In the laboratory this can be achieved by heating and adding acids or bases. In biological systems evolution has developed enzymes as biological catalysts that are able to catalyze all necessary reactions without higher temperatures being necessary. Enzymes do not change the reaction equilibrium, but usually alter the reaction rate. Enzymes contain an active center in which a substrate is bound.

Through x-ray and nuclear magnetic resonance (NMR) analysis, the spatial structures of many hundreds of proteins have been determined. Structure analysis is a challenge not only for basic research, but also for applied pharmaceutical research. If the structure or binding sites of a receptor or enzyme are known in detail, it should be possible to design new active substances that have the correct fit and act either as an agonist or antagonist. Successes in rational drug design so far concern active substances in the area of AIDS (HIV protease inhibitors; Viracept, Agenerase) and influenza (neuraminidase inhibitors: Relenza, Tamiflu).

17 Structure of nucleotides. (A) Structures of purine and pyrimidine bases, pentoses, and ATP (as an example of a nucleotide). (B) Structures of ATP, AMP, ADP, glucose, FAD+, and coenzyme A. 4 Structure of Nucleotides and Nucleic Acids (DNA and RNA) 23 Fig. 18 Linear structure of DNA and RNA. In nucleic acid biosynthesis the a-positioned phosphate group of a nucleotide triphosphate (NTPs in RNA; dNTPs in DNA) is linked to the free 3'-OH group of the available strand. 6 Nomenclature of DNA and RNA building blocks.

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An Introduction to Molecular Biotechnology- Fundamentals, Methods and Applications by Michael Wink


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