New PDF release: An Introduction to Molecular Medicine and Gene Therapy

By Thomas F. Kresina

ISBN-10: 0471391883

ISBN-13: 9780471391883

ISBN-10: 0471461040

ISBN-13: 9780471461043

An advent to Molecular medication and Gene treatment Edited by means of Thomas F. Kresina, Ph.D. Gene treatment, or using genetic manipulation for disorder therapy, is derived from advances in genetics, molecular biology, medical medication, and human genomics. Molecular medication, the applying of molecular organic recommendations to affliction therapy and analysis, is derived from the improvement of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An advent to Molecular medication and Gene treatment presents a foundation for reading new scientific and simple learn findings within the components of cloning, gene move, and concentrating on; the purposes of genetic drugs to scientific stipulations; ethics and governmental rules; and the burgeoning fields of genomics, biotechnology, and bioinformatics. by means of dividing the fabric into 3 sections - an creation to easy technology, a assessment of scientific purposes, and a dialogue of the evolving matters on the topic of gene remedy and molecular medicine-this finished handbook describes the fundamental methods to the huge diversity of exact and capability genetic-based remedies. moreover, An advent to Molecular medication and Gene remedy: * Covers new frontiers in gene treatment, animal versions, vectors, gene concentrating on, and ethical/legal issues * presents organ-based reports of present reviews in gene treatment for monogenetic, multifactoral or polygenic problems, and infectious ailments * contains bold-faced phrases, key recommendations, summaries, and lists of useful references by means of topic in each one bankruptcy * includes appendices on advertisement implications and a evaluate of the heritage of gene remedy This textbook deals a transparent, concise writing kind, drawing upon the services of the authors, all popular researchers of their respective specialties of molecular medication. Researchers in genetics and molecular medication will all locate An advent to Molecular medication and Gene treatment to be a vital advisor to the quickly evolving box of gene remedy and its functions in molecular drugs.

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Additional resources for An Introduction to Molecular Medicine and Gene Therapy

Example text

Human Gene Therapeutics. Chapman and Hall, London, 1995, pp. 195–236. Francisco M. Gene therapy: Better vectors, less hype. Nat Biotech 15:815, 1997. Morgan RA, Blaese RM. Gene therapy: Lessons learnt from the past decade. Br Med J 319:1310, 1999. Mulligan RC. The basic science of gene therapy. Science 260:926–932, 1993. Schwertz DW, McCormick KM. The molecular basis of genetics and inheritance. J Cardiovasc Nurs 13:1–18, 1999. Stephenson J. Gene therapy trial show clinical efficacy. JAMA 283:589–590, 2000.

The genome can respond to the signals it receives in many ways, some of which are positive for the host and some of which could be detrimental to the host. For example, based on environmental stimuli the genome can up-regulate genes necessary for normal physiology, such as those encoding antiviral antibodies. Alternatively, the stimuli can upregulate genes that accelerate a pathogenic process, such as those encoding autoantibodies. The goal of innovative medical interventions, such as gene therapy, is to accentuate the positive potential of gene expression and eliminate or circumvent the negative.

Verma IM, Somia N. Gene therapy—promises, problems and prospects. Nature 389:239–242, 1997. Wadman M. NIH panel to limit secrecy on gene therapy. Nature 402:6, 1999. DNA Vaccines Arntzen CJ. High-tech herbal medicine: Plant-based vaccines. Nat Biotech 15:221–222, 1997. Donnelly JJ, Ulmer JB, Shiver JW, Liu MA. DNA vaccines. Annu Rev Immunol 15:617–648, 1997. Mancini M, Davis H, Tiollais P, Michel ML. DNA-based immunization against the envelope proteins of the hepatitis B virus. J Biotech 44:47–57, 1996.

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An Introduction to Molecular Medicine and Gene Therapy by Thomas F. Kresina


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