Download PDF by Shaker A. Mousa: Angiogenesis Inhibitors and Stimulators: Potential

By Shaker A. Mousa

ISBN-10: 0585415439

ISBN-13: 9780585415437

ISBN-10: 1587060221

ISBN-13: 9781587060229

Angiogenesis Inhibitors and Stimulators is a quantity within the clinical Intelligence Unit sequence. It describes new blood vessel improvement in melanoma and in benign illness, specially in regards to strength treatment. The e-book has 15 chapters and 31 participants.

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Extra info for Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications (Medical Intelligence Unit)

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Vikkula M, Boon LM, Carraway III KL, et al. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 1996; 87:1181-90. The Role of Smooth Muscle Cells and Pericytes in Angiogenesis 33 8. Levéen P, Pekny M, Gebre-Medhin S, et al. Mice deficient for PDGF β show renal, cardiovascular, and hematological abnormalities. Genes Dev 1994; 8:1875-1887. 9. Soriano P. Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes Dev 1994;8:1888-1896.

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochem Biophys Acta 1993; 1155:357-371. 87. Grant DS, Kleinman HK, Goldberg ID, et al. Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 1993; 90:1937-1941. 88. Rosen EM, Goldberg ID, Kacinski BM, et al. Smooth muscle releases an epithelial cell scatter factor which binds to heparin. In Vitro Cell Develop Biol 1989; 25:163-173. 89. Nakamura Y, Morishita R, Higaki J, et al. Expression of local hepatocyte growth factor system in vascular tissues.

These data demonstrate the contribution of SMCs to vessel formation that occurs in response to ischemia and growth factors. The Role of SMCs in Controlling Flow to the Capillary Bed Smooth muscle cells are an important regulator of blood flow to capillary beds where angiogenesis is initiated. Not all of the vessels that form during angiogenesis develop into mature collaterals. The competition for blood flow causes variable shear stress forces in the vessel which can cause the over-proliferation of SMCs (intimal hyperplasia) and ultimately lead to the occlusion of the smaller Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications, edited by Shaker A.

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Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications (Medical Intelligence Unit) by Shaker A. Mousa


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