By Harald Kropshofer, Anne B. Vogt
This novel, multidisciplinary instruction manual highlights contemporary facts that antigen proposing cells (APCs) aren't merely key gamers within the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune reaction, but in addition severe regulators and integrators within the interaction among our innate and adaptive immune system.Structured in a transparent option to permit entry to a really wide readership, the e-book is written from the perspective of a biochemist, immunologist, and scientist with adventure in drug improvement. It covers all mobilephone kinds considering antigen presentation, supplying the most recent immunological proof with a spotlight on drug improvement. sponsored through a thesaurus explaining all vital technical phrases, this brief yet complete reference covers simple introductory elements correct as much as info for complex experts.
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Extra resources for Antigen Presenting Cells: From Mechanisms to Drug Development
1997, 159, 2574–2579. Allen PM, Strydom DJ, Unanue ER. Processing of lysozyme by macrophages: identification of the determinant recognized by two T cell hybridomas. Proc. Natl. Acad. Sci. A. 1984, 81, 2489–2495. Ziegler K, Unanue ER. Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to lymphocytes. J. Immunol. 1981, 127, 1869–1877. Ziegler K, Unanue ER. Decrease in macrophage antigen catabolism by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.
50 Viner NJ, Nelson CA, Unanue ER. Idenk tification of a major I–E -restricted determinant of hen egg lysozyme: Limitations of lymph node proliferation studies in defining immunodominance and crypticity. Proc. Natl. Acad. Sci. A. 1995, 92, 2214–2218. 51 Viner NJ, Nelson CA, Deck B, Unanue ER. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J. Immunol. 1996, 156, 2365–2368. 52 Cirrito TP, Pu Z, Deck MB, Unanue ER.
F6 APC line. (A) cultured with HEL; (B) cultured with HEL. Note the many peaks of autologous peptides in both parts; and the prominent peak of the chemically dominant 48-62 peptide in (B). (From Ref. ) lines handled HEL identically, as if the soluble protein had been offered as an exogenous protein. The lines have the advantage that the mHEL gene can be mutated, allowing different residues in peptide selection and presentation to be 5 6 1 Some Old and Some New Findings on Antigen Processing and Presentation evaluated.
Antigen Presenting Cells: From Mechanisms to Drug Development by Harald Kropshofer, Anne B. Vogt