Antioxidants and Cardiovascular Disease by Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, PDF

By Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)

ISBN-10: 0387295526

ISBN-13: 9780387295527

ISBN-10: 0387295534

ISBN-13: 9780387295534

Antioxidants and heart problems, moment version addresses a posh yet very well timed and interesting challenge in cardiovascular drugs. it's written by way of famous specialists within the fields of atherosclerosis and antioxidants. it may be of curiosity not just to academicians but additionally to practising physicians. the 1st 5 chapters overview the final recommendations of oxidative tension and their dating to lipid metabolism, endothelial disorder, genetics and transcriptional elements. the subsequent seven chapters describe lately outlined markers of oxidative tension, pharmacological compounds with antioxidant task, traditional antioxidants present in micronutrients and in nutrient-rich diets, and studies the hot proof for his or her efficacy or loss of efficacy in sufferers with heart problems or cardiovascular possibility components. The final seven chapters speak about the aptitude healing merits of antioxidants in a couple of cardiovascular stipulations which come with atherosclerosis, restenosis after percutaneous coronary intervention, significant cardiovascular probability elements comparable to high blood pressure, diabetes mellitus and dyslipidemia, and left ventricular disorder and congestive center failure.

Martial G. Bourassa, M.D. and Jean-Claude Tardif, M.D. are affiliated with the Montreal middle Institute, study middle and division of medication, college of medication, collage of Montreal, Montreal, Quebec, Canada.

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Circulation 2001;103:2277-82. Podrez EA, Schmitt D, Hoff HF, et al. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. J Clin Invest 1999;103:1547-60. Zhang R, Brennan ML, Shen Z, et al. Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. J Biol Chem 2002;277:46116-22. Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 2003;349:1595-604.

3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 2002;8:1211-17. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-74. Napoli C, D'Armiento FP, Mancini FP et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of Low Density Lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.

Napoli C, D'Armiento FP, Mancini FP et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of Low Density Lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 1997;100:2680-90. Napoli C, Glass CK, Witztum JL et al. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study.

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Antioxidants and Cardiovascular Disease by Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)


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