Read e-book online The Long and Short Non-coding RNAs in Cancer Biology PDF

By Erwei Song

ISBN-10: 9811014965

ISBN-13: 9789811014963

ISBN-10: 9811014981

ISBN-13: 9789811014987

The ebook conveys a entire wisdom of lengthy and brief ncRNAs in melanoma legislation and their potentials as diagnostic biomarkers and healing objectives. subject matters coated contain the molecular mechanisms of varied sessions of ncRNAs (with emphasis on lengthy non-coding RNAs and microRNAs) in melanoma, the useful roles of ncRNAs in regulating diverse melanoma hallmarks (including proliferation, apoptosis, stem-cell homes, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and healing resistance), the position of ncRNAs in regulating melanoma signaling circuitry courses (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic precis of medical and preclinical reports that overview the possibility of ncRNA signatures for melanoma prognosis and analysis and techniques to supply brief ncRNAs as healing molecules for melanoma remedy. This booklet may perhaps function a finished source for researchers, graduate scholars and oncologists in ncRNA and melanoma study and aid drug improvement by way of deciding on ncRNA objectives.

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Extra resources for The Long and Short Non-coding RNAs in Cancer Biology

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The housekeeping ncRNAs have a broad range of roles, such as adaptors (tRNAs) and ribosomal components (rRNAs) during translation, the spliceosome in splicing (snRNAs), and RNA maturation including editing (snoRNAs). Current investigations have found their involvement in cancer. For example, tRNA synthesis is positively regulated by oncogenes (ERK, TORC1, Myc) and negatively modulated by tumor suppressors (Maf1, p53, Rb) through selective effects on Pol III activity, which then influences mRNA translation and tumor growth [348].

Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 2009;23(18):2152–65. 68. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs—the micro steering wheel of tumour metastases. Nat Rev Cancer. 2009;9(4):293–302. 69. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010;143(1):46–58. 175. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE. 2012;7(2):e30733. 176. Yang L, Duff MO, Graveley BR, Carmichael GG, Chen L-L. Genomewide characterization of non-polyadenylated RNAs. Genome Biol. 2011;12(2):R16. 177. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M.

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The Long and Short Non-coding RNAs in Cancer Biology by Erwei Song

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